Key result
IgG autoantibodies from patients with dilated cardiomyopathy triggered β1-adrenergic receptor conformation changes and attenuated receptor internalization compared to healthy controls.
Why the study?
Do autoantibodies from patients with dilated cardiomyopathy alter β1-adrenergic receptor conformation, activity, and internalization?
Case-Control (n=22)
Do autoantibodies from patients with dilated cardiomyopathy alter β1-adrenergic receptor conformation, activity, and internalization?
Absolute Event Rate: 80% vs 10%
Autoantibodies from patients with dilated cardiomyopathy alter β1-adrenergic receptor conformation and internalization, providing a mechanistic basis for autoantibody-induced myocardial dysfunction.
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May implicate autoantibodies in DCM progression; leaves open therapeutic targeting in humans.
Bornholz et al. (2012) conducted a case-control in Dilated cardiomyopathy (n=22). Autoantibodies (IgG) from patients with dilated cardiomyopathy vs. IgG from matched healthy donors or commercial preparations was evaluated on Detection of receptor-activating IgG. IgG autoantibodies from patients with dilated cardiomyopathy triggered β1-adrenergic receptor conformation changes and attenuated receptor internalization compared to healthy controls.
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