Key result
Aspirin enhances the osteogenic potential of periodontal ligament stem cells and modulates growth factor-associated genes, suggesting a supportive role in periodontal regeneration.
Why the study?
PDLSCs offer potential for stem cell-based therapy and bone regeneration, and aspirin is known to modulate various diseases, but its impacts on stem cells and growth factors needed review.
Aspirin enhances the osteogenic potential of periodontal ligament stem cells and modulates growth factor expression, suggesting potential applications in regenerative dentistry.
The periodontal ligament (PDL) contains a unique population of mesenchymal stem cells (MSCs), also known as PDL stem cells (PDLSCs). The regenerative properties of PDLSCs offer much potential for stem cell-based therapy, particularly for periodontal or bone regeneration. Aspirin (ASA) is a widely used nonsteroidal anti-inflammatory drug (NSAID) that has been reported to modulate a variety of diseases, such as cardiovascular, diabetes, and cancer. This review article focuses on the impacts of ASA on various stem cells. First, we will explain what constitutes PDLSCs and their derivation from periodontal tissues. Then we will discuss the mechanisms of ASA and its effect on periodontal tissues. Next, we focus on aspirin’s effects on the differentiation of various types of stem cells. Finally, we investigate the effects of ASA on growth factors that could enhance the osteoblastic potential of derived stem cells.
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Rahman et al. (2023) conducted a review in Periodontal and bone regeneration. Aspirin (Acetylsalicylic acid) was evaluated. Aspirin enhances the osteogenic potential of periodontal ligament stem cells and modulates growth factor-associated genes, suggesting a supportive role in periodontal regeneration.
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