Daily administration of an inhibitor of 5 alpha-reductase, 17 beta-testosterone carboxylic acid, significantly attenuated the stimulatory effect of testosterone propionate on penile erections displayed by castrated male rats which were restrained in a supine position. This treatment, however, failed to affect mating behavior in tests with sexually receptive females. The inhibitory effect of 17 beta-testosterone carboxylic acid on erection was reversed by concurrent administration of 5 alpha-dihydrotestosterone propionate, suggesting that the 5 alpha-reduced metabolite(s) of testosterone may normally contribute to the activation of penile erection in the rat.
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Bradshaw et al. (1981) studied this question.
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