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April 28, 2017International Clinical Pathology JournalOpen Access

Transcatheter Aortic Valve Replacement

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Why the study?

Does transcatheter aortic valve replacement improve outcomes in patients with severe symptomatic aortic stenosis compared to surgical aortic valve replacement?

Population

Patients with severe symptomatic aortic stenosis, particularly those over age 65, including inoperable…

Comparison

Transcatheter aortic valve replacement using… vs Conventional surgical aortic valve replacement

Design

Review

Key result

Transcatheter aortic valve replacement is an effective treatment for inoperable patients and a reliable alternative to conventional surgical aortic valve replacement in high- and intermediate-risk patients with severe aortic stenosis.

Authors

FVFelippe Dantas Vilela

Discussion

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Overview

TAVR has become a standard of care for inoperable and high-risk patients with severe aortic stenosis, with expanding indications into intermediate and potentially low-risk populations.

Structured PICO

Does transcatheter aortic valve replacement improve outcomes in patients with severe symptomatic aortic stenosis compared to surgical aortic valve replacement?

P
Population
Patients with severe symptomatic aortic stenosis, particularly those over age 65, including inoperable, high-risk, and intermediate-risk surgical candidates.
I
Intervention
Transcatheter aortic valve replacement (TAVR) using various bioprosthetic valves
C
Comparator
Conventional surgical aortic valve replacement (SAVR)

TAVR has become a standard of care for inoperable and high-risk patients with severe aortic stenosis, with expanding indications into intermediate and potentially low-risk populations.

Limitations

  • Extrapolation of trial results to younger age groups is problematic given the lack of long-term durability data.
  • Transcatheter aortic valves are likely to degenerate with time and may eventually require repeat intervention.
  • Lack of long-term durability data beyond 5 years
  • Need for more studies to confirm long-term durability and clinical gains in less fragile and less morbid patients

Cite This Study

Felippe Dantas Vilela (2017) conducted a review in Severe aortic stenosis. Transcatheter aortic valve replacement (TAVR) vs. Surgical aortic valve replacement (SAVR) was evaluated. Transcatheter aortic valve replacement is an effective treatment for inoperable patients and a reliable alternative to conventional surgical aortic valve replacement in high- and intermediate-risk patients with severe aortic stenosis.

synapsesocial.com/papers/6a899877abe412682d92f2a7https://doi.org/10.15406/icpjl.2017.04.00104
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Survival in elderly patients with severe aortic stenosis is dramatically improved by aortic valve replacement: results from a cohort of 277 patients aged ≥80 years☆2006 · 229 citations
  2. 2Percutaneous Transcatheter Implantation of an Aortic Valve Prosthesis for Calcific Aortic Stenosis2002 · 3,189 citations
  3. 3Transcatheter versus Surgical Aortic-Valve Replacement in High-Risk Patients2011 · 6,381 citations
  4. 4Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients2016 · 5,098 citations
  5. 5Transcatheter Aortic-Valve Implantation for Aortic Stenosis in Patients Who Cannot Undergo Surgery2010 · 7,231 citations