Why the study?
Does halothane anesthesia compared to other general anesthetic agents affect the incidence of fatal massive hepatic necrosis and overall death rate in patients undergoing general anesthesia?
Population
Patients undergoing general anesthesia in 34 hospitals from 1959 through 1962
Comparison
Halothane anesthesia vs Other general anesthetic agents
Design
Cohort
Follow-up
six-week period following surgery
Authors
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Institutional variation in postoperative mortality cautions against uniform outcome expectations; leaves open whether anesthetic agents drive differences.
Does halothane anesthesia compared to other general anesthetic agents affect the incidence of fatal massive hepatic necrosis and overall death rate in patients undergoing general anesthesia?
There is a wide, 24-fold variation in six-week postoperative death rates across different institutions following general anesthesia.
L. E. Moses (1968) studied this question.
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