Key result
Overweight and obesity were associated with increased risks of all-cause and coronary heart disease mortality in middle-aged men both with and without prevalent coronary heart disease.
Why the study?
Does obesity and overweight increase the risk of disease-specific mortality in men with and without existing coronary heart disease?
Population
18,403 middle-aged male government employees in London, with and without prevalent coronary heart disease at…
Comparison
Overweight and obesity vs Normal weight (BMI 18.5 to <25.0 kg/m2)
Design
Cohort
Follow-up
maximum of 35 years
Authors
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Should not yet change practice; extends observational links of overweight/obesity to higher mortality in middle-aged men with or without CHD.
Cohort (n=18,403)
Does obesity and overweight increase the risk of disease-specific mortality in men with and without existing coronary heart disease?
Hazard Ratio: 1.28 (95% CI 1.11–1.47)
Absolute Event Rate: 15.7% vs 12.4%
p-value: p=<0.001
Avoidance of obesity and overweight in adult life may reduce the long-term risk of total and CHD mortality in men, regardless of whether they have pre-existing coronary heart disease.
G. David Batty (2005) conducted a cohort in Coronary heart disease (prevalent and non-prevalent) (n=18,403). Overweight and obesity (BMI ≥25.0 kg/m²) vs. Normal weight (BMI 18.5 to <25.0 kg/m²) was evaluated on Coronary heart disease mortality in men with baseline CHD (overweight vs normal weight) (HR 1.28, 95% CI 1.11-1.47, p=<0.001). Overweight and obesity were associated with increased risks of all-cause and coronary heart disease mortality in middle-aged men both with and without prevalent coronary heart disease.
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