Key result
Moderate to severe obstructive sleep apnea syndrome was associated with significantly higher pulmonary artery stiffness compared to controls (28±5 vs 18±4 kHz/s, p<0.001).
Why the study?
Is moderate to severe obstructive sleep apnea associated with increased pulmonary artery stiffness, aortic stiffness, and left ventricular abnormalities?
Cross-Sectional (n=66)
No
Is moderate to severe obstructive sleep apnea associated with increased pulmonary artery stiffness, aortic stiffness, and left ventricular abnormalities?
Absolute Event Rate: 28% vs 18%
p-value: p=<0.001
In patients with moderate to severe OSAS, increased pulmonary artery stiffness is associated with aortic stiffness and left ventricular abnormalities, suggesting it may serve as an effective indicator of cardiovascular risk.
May indicate cardiovascular risk in moderate-severe OSAS; leaves open whether stiffness predicts outcomes or warrants intervention.
OBJECTIVE: In this study, the associations between pulmonary artery stiffness (PAS) and aortic stiffness, left ventricular diastolic parameters, and left ventricular mass (LVM) index in moderate to severe obstructive sleep apnea syndrome (OSAS) patients without coexisting disorders were investigated. METHODS: A total of 66 non-diabetic, non-hypertensive, and non-smoking volunteers were enrolled. Participants were categorized by apnea-hypopnea index (AHI; event/hour). The control group was defined as no OSAS: AHI<5 (n=35), and OSAS group had moderate to severe OSAS: AHI>15 (n=31).Echocardiographic and biochemical tests, including measurement of C-reactive protein (CRP), were performed. PAS (kHz/s) was calculated by dividing the maximal frequency shift of the pulmonary flow by the acceleration time. RESULTS: PAS (kHz/s), obtained by echocardiography, was statistically significantly higher in the OSAS group than the control group (28±5 vs 18±4, p<0.001), and was positively correlated with AHI, CRP, aortic stiffness index, E/E', and LVM index (p=0.034, p=0.039, p<0.001, p=0.040, and p<0.001, respectively), and negatively correlated with aortic strain (AS), aortic distensibility (AD), E/A, E'/A', and E' (p<0.001). Regression analyses indicated that CRP and PAS are independent predictors of aortic stiffness (p<0.05). E/A and LVM index were independent predictors of PAS (p=0.002 and p=0.001, respectively). CONCLUSION: Increased PAS is associated with aortic stiffness, left ventricular diastolic function, and increased LVM index. PAS may be a more effective indicator of aortic stiffness in OSAS patients than CRP.
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İbrahim Halil Altıparmak (2016) conducted a cross-sectional in Obstructive sleep apnea syndrome (n=66). Moderate to severe obstructive sleep apnea syndrome vs. No OSAS (AHI < 5) was evaluated on Pulmonary artery stiffness (PAS) in kHz/s (p=<0.001). Moderate to severe obstructive sleep apnea syndrome was associated with significantly higher pulmonary artery stiffness compared to controls (28±5 vs 18±4 kHz/s, p<0.001).
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