Key result
Higher severity of untreated obstructive sleep apnoea-hypopnoea syndrome was significantly associated with deteriorated left ventricular diastolic function and aortic elastic parameters.
Why the study?
Is untreated obstructive sleep apnoea-hypopnoea syndrome (OSAHS) associated with left ventricular dysfunction and aortic root dilatation?
Observational (n=90)
Is untreated obstructive sleep apnoea-hypopnoea syndrome (OSAHS) associated with left ventricular dysfunction and aortic root dilatation?
Untreated obstructive sleep apnea is associated with deterioration in left ventricular diastolic function and aortic elastic parameters, highlighting its structural cardiovascular impact.
Untreated OSAHS severity was associated with worse LV diastolic and aortic parameters; hypothesis-generating, prospective trials needed before practice change.
This prospective study investigated whether untreated obstructive sleep apnoea-hypopnoea syndrome (OSAHS), which is strongly associated with cardiovascular disease, is a risk factor for left ventricular (LV) systolic and diastolic dysfunction and aortic root dilatation. Ninety consecutive patients with breathing and snoring problems, including 64 with newly diagnosed, untreated OSAHS, were classified into four groups based on their apnoea-hypopnoea index (AHI). All participants underwent overnight polysomnographic and complete echocardiographic examinations, and LV systolic, diastolic and aortic measurements were compared. Body mass index was the only demographic characteristic that significantly increased as the severity of OSAHS (AHI) increased and it significantly correlated with AHI. Patients with a higher AHI had a significantly higher aortic root diameter and aortic stiffness index, and significantly lower aortic strain. The LV diastolic parameters were least favourable in patients with more severe OSAHS. The LV ejection fraction did not differ significantly between groups. It was concluded that LV diastolic function and aortic elastic parameters deteriorate with OSAHS.
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Lakadamyalı et al. (2011) conducted an observational in Obstructive sleep apnoea-hypopnoea syndrome (OSAHS) (n=90). Obstructive sleep apnoea-hypopnoea syndrome (OSAHS) vs. Lower severity or absence of OSAHS was evaluated on Left ventricular systolic and diastolic function and aortic root parameters. Higher severity of untreated obstructive sleep apnoea-hypopnoea syndrome was significantly associated with deteriorated left ventricular diastolic function and aortic elastic parameters.
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