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Epigenetic silencing of tumor suppressor genes (TSGs) is critical for glioma initiation and progression. Emerging reports suggest that increased numbers of TSGs, which are critical to cell cycle, proliferation, apoptosis, migration, invasion, DNA repair, and signaling pathways, were silenced in gliomas. Tumor-specific methylation of TSGs in glioma indicates that they could be used as epigenetic biomarkers for molecular diagnosis and therapeutics. This review summarizes the recent discoveries of epigenetically silenced TSGs in human gliomas, providing better understanding of disrupted epigenetic regulation in glioma progression.
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Cheng et al. (2015) studied this question.
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