Key result
Kalirin and CHD7 levels in circulating extracellular vesicles were increased in albuminuric hypertensive patients and positively correlated with the endothelial activation marker E-selectin.
Population
Hypertensive patients with albuminuria and in vitro TNFα-treated adult human endothelial cells
Design
Cross-sectional
Authors
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May support EV-based endothelial biomarkers in albuminuric hypertension; leaves open validation and prognostic utility in prospective studies.
Observational
Kalirin and CHD7 in circulating extracellular vesicles may serve as novel biomarkers for endothelial dysfunction to monitor vascular condition in hypertensive patients with albuminuria.
Cuesta et al. (2017) conducted an observational in Hypertension with albuminuria. Kalirin and CHD7 in circulating extracellular vesicles was evaluated on Protein levels of kalirin and CHD7 and correlation with E-selectin. Kalirin and CHD7 levels in circulating extracellular vesicles were increased in albuminuric hypertensive patients and positively correlated with the endothelial activation marker E-selectin.