A simple method for the synthesis of quinazolines was developed by exploiting the “tert-amino effect.” A catalytic amount of Brønsted acid (TsOH·H2O) worked as an effective activator for the concise construction of a quinazoline framework from o-formylaniline and amine.
No takes yet. Share an insight, caveat, or question.
Mori et al. (2009) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: