What question did this study set out to answer?

To develop an efficient, site-selective strategy for the remote δ-selective Csp3–H bond functionalization of non-activated, abundant aliphatic alcohols.

July 2, 2018Nature CommunicationsOpen Access

Silver-catalyzed remote Csp3-H functionalization of aliphatic alcohols

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To develop an efficient, site-selective strategy for the remote δ-selective Csp3–H bond functionalization of non-activated, abundant aliphatic alcohols.
Applied a silver-catalytic system to facilitate remote functionalization of simple, unactivated aliphatic alcohols.
Employed custom-designed sulphonyl reagents to direct the reaction under simple and mild operational conditions.
Achieved remote δ-selective functionalization of unactivated Csp3–H bonds across aliphatic alcohol substrates.
Formed challenging δ-selective C–C bonds to efficiently generate oximonitrile-substituted alcohol products.

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Implication

Experimental study demonstrates silver-catalyzed delta-selective Csp3-H functionalization of aliphatic alcohols, highlighting an efficient route to access oximonitrile derivatives.

Cite This Study

Zhu et al. (2018) studied this question.

synapsesocial.com/papers/6a89a479451a22fc7efb8fe1 https://doi.org/10.1038/s41467-018-05014-w

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Implication

Experimental study demonstrates silver-catalyzed delta-selective Csp3-H functionalization of aliphatic alcohols, highlighting an efficient route to access oximonitrile derivatives.

Silver-catalyzed remote Csp3-H functionalization of aliphatic alcohols

Key Points

Discussion

Implication

Cite This Study

Silver-catalyzed remote Csp3-H functionalization of aliphatic alcohols

Key Points

Discussion

Implication

Cite This Study

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