Key result
The a allele of the eNOS intron 4 VNTR polymorphism was associated with delayed graft function after first renal transplantation, but not with acute or chronic rejection.
Why the study?
Is the eNOS intron 4 VNTR polymorphism associated with delayed graft function or rejection in first renal transplant recipients?
Observational (n=187)
Is the eNOS intron 4 VNTR polymorphism associated with delayed graft function or rejection in first renal transplant recipients?
The a allele of the eNOS intron 4 VNTR polymorphism may predispose first renal transplant recipients to delayed graft function.
Hypothesis-generating for eNOS variants in delayed graft function; prospective validation needed before any clinical use.
Dutkiewicz G, Domanski L, Binczak‐Kuleta A, Pawlik A, Safranow K, Ciechanowicz A, Dziedziejko V, Ciechanowski K. The association betweeneNOSintron 4 VNTR polymorphism and delayed graft function of kidney allografts. Clin Transplant 2009 DOI: 10.1111/j.1399‐0012.2009.01187.x © 2009 John Wiley & Sons A/S. Abstract: Nitric oxide (NO) is a multifunctional agent which serves as a key signaling molecule in physiological processes such as host defense, neuronal communication, and the regulation of vascular tone. Different polymorphic variations have been identified in the humanNOS3(eNOS) gene.The aim of the present study was to examine the association between polymorphisms of theNOS3gene (G894T substitution within exon 7 and intron 4 VNTR polymorphism) and the development of delayed graft function as well as acute and chronic rejection.One hundred eighty‐seven recipients of first renal transplants were included in the study. There were no significant associations between these polymorphisms and acute and chronic kidney allograft rejection. The intron 4 polymorphism was associated with delayed graft function after transplantation. The results of this study suggest that patients with the a allele of theeNOSintron 4 VNTR polymorphism may be predisposed to delayed graft function.
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Dutkiewicz et al. (2009) conducted an observational in Kidney allograft recipients (n=187). NOS3 gene polymorphisms (G894T substitution and intron 4 VNTR polymorphism) vs. Patients without the specific alleles was evaluated on Delayed graft function, acute and chronic rejection. The a allele of the eNOS intron 4 VNTR polymorphism was associated with delayed graft function after first renal transplantation, but not with acute or chronic rejection.
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