Key result
Treatment of porcine cell lines with IFN-gamma or IFN-alpha enhanced PCV2 infection, with IFN-gamma causing a 20-fold higher production of progeny virus.
Population
Porcine kidney cells (PK-15) and porcine monocytic cells (3D4/31) inoculated with porcine circovirus 2 (PCV2)
Comparison
Cytokines added to culture medium before… vs Untreated cells
Design
Preclinical
Authors
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IFN-gamma may promote PCV2 replication in vitro; leaves open whether this occurs in vivo or influences porcine disease.
IFN-gamma and IFN-alpha enhance PCV2 infection in porcine cell lines, representing the first report of viral infection enhancement by type I or type II IFNs.
Meerts et al. (2005) studied Porcine circovirus 2 (PCV2) infection. IFN-gamma and IFN-alpha vs. Untreated cells was evaluated on Number of PCV2 antigen-positive cells and progeny virus production. Treatment of porcine cell lines with IFN-gamma or IFN-alpha enhanced PCV2 infection, with IFN-gamma causing a 20-fold higher production of progeny virus.
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