Key result
Co-administration of NSAIDs was associated with an increased risk of cisplatin-induced nephrotoxicity (OR 1.88; 95% CI 1.44-2.45).
Why the study?
Previous studies demonstrated NSAIDs as a risk factor for cisplatin-induced nephrotoxicity, prompting a comprehensive meta-analysis to evaluate their findings.
Does NSAIDs co-administration increase the risk of cisplatin-induced nephrotoxicity in patients receiving cisplatin chemotherapy?
Meta-Analysis
Does NSAIDs co-administration increase the risk of cisplatin-induced nephrotoxicity in patients receiving cisplatin chemotherapy?
Odds Ratio: 1.88 (95% CI 1.44–2.45)
Co-administration of NSAIDs with cisplatin significantly increases the risk of cisplatin-induced nephrotoxicity.
NSAIDs warrant caution or avoidance with cisplatin; supports heightened nephrotoxicity risk and alternative analgesia strategies.
BACKGROUND/AIM: Previous reports have demonstrated that non-steroidal anti-inflammatory drugs (NSAIDs) are a risk factor for cisplatin-induced nephrotoxicity (CIN). Here, the results of these previous studies were comprehensively assessed via a meta-analysis. MATERIALS AND METHODS: After a database search to select eligible studies, a meta-analysis was performed using a forest plot, followed by an assessment of the heterogeneity and publication bias and a subgroup analysis. RESULTS: Seven studies were extracted as candidates. All were retrospective studies and evaluated the effect of NSAIDs on CIN as a secondary endpoint. According to the meta-analysis, total odds ratio was 1.88 (95% confidence interval=1.44-2.45). Further, high heterogeneity and publication bias were not observed. A subgroup analysis of the chemotherapy evaluation period revealed that CIN tended to be enhanced in the first course group (evaluation in only 1 course) and was significantly enhanced in the total course group (evaluation in 1 or more courses) by NSAIDs co-administration. CONCLUSION: NSAIDs co-administration could be a risk factor for CIN.
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Okamoto et al. (2020) conducted a meta-analysis in Cisplatin-induced nephrotoxicity. Non-steroidal anti-inflammatory drugs (NSAIDs) was evaluated on Cisplatin-induced nephrotoxicity (CIN) (OR 1.88, 95% CI 1.44-2.45). Co-administration of NSAIDs was associated with an increased risk of cisplatin-induced nephrotoxicity (OR 1.88; 95% CI 1.44-2.45).
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