A strategy based on the use of (trifluoromethyl) trimethylsilane for introduction of the trifluoromethyl group at the C-4 of ribose has been developed and utilized in the synthesis of various novel 4′-trifluoromethylated nucleoside analogs. Screening of these analogs against HIV did not reveal significant biological activity.
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Kozak et al. (1998) studied this question.
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