Key result
Aldosterone stimulates human mesangial cell proliferation through mineralocorticoid receptor-mediated, redox-sensitive EGFR transactivation dependent on Ras/MAPK and PI3K/Akt/mTOR signaling pathways.
Aldosterone induces human mesangial cell proliferation via MR-mediated, redox-sensitive EGFR transactivation and downstream MAPK/PI3K pathways.
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Hypothesis-generating for MR/EGFR inhibition in glomerular disease; requires in vivo and clinical validation before practice change.
Huang et al. (2009) studied Aldosterone-induced mesangial cell proliferation. Aldosterone vs. Various pathway inhibitors was evaluated on Mesangial cell proliferation. Aldosterone stimulates human mesangial cell proliferation through mineralocorticoid receptor-mediated, redox-sensitive EGFR transactivation dependent on Ras/MAPK and PI3K/Akt/mTOR signaling pathways.
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