Key result
Kcne2 deletion in mice resulted in a 40% lower infarct size and preserved post-infarct cardiac function following ischaemia/reperfusion injury compared with wild-type mice.
Why the study?
Does Kcne2 deletion reduce infarct size and tissue damage in a mouse model of acute ischaemia/reperfusion injury?
Does Kcne2 deletion reduce infarct size and tissue damage in a mouse model of acute ischaemia/reperfusion injury?
Kcne2 deletion preconditions the heart and attenuates acute tissue damage caused by ischaemia/reperfusion injury, likely via GSK-3β inactivation.
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May precondition against murine ischaemia/reperfusion injury; leaves open translation to human cardioprotection.
Hu et al. (2016) studied Myocardial infarction (ischaemia/reperfusion injury). Kcne2 deletion vs. Kcne2+/+ mice was evaluated on Infarct size and markers of tissue damage. Kcne2 deletion in mice resulted in a 40% lower infarct size and preserved post-infarct cardiac function following ischaemia/reperfusion injury compared with wild-type mice.
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