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November 23, 2013Journal of Cellular PhysiologyOpen Access

Acetylsalicylic Acid Inhibits IL-18-Induced Cardiac Fibroblast Migration Through the Induction of RECK

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Key result

Acetylsalicylic acid inhibited IL-18-induced cardiac fibroblast migration by attenuating H2O2 generation, MMP9 activation, and RECK suppression.

Why the study?

Does acetylsalicylic acid inhibit IL-18-induced cardiac fibroblast migration in primary mouse cardiac fibroblasts?

Population

Primary mouse cardiac fibroblasts

Comparison

Acetylsalicylic acid at therapeutic concentrations vs Control (IL-18 stimulation without ASA)

Design

Preclinical

Authors

JSJalahalli M. SiddeshaAVAnthony J. ValenteSSSiva S. V. P. Sakamuri

Discussion

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Overview

Hypothesis-generating for acetylsalicylic acid in cardiac fibrosis; requires human validation before clinical consideration.

Structured PICO

Does acetylsalicylic acid inhibit IL-18-induced cardiac fibroblast migration in primary mouse cardiac fibroblasts?

P
Population
Primary mouse cardiac fibroblasts
I
Intervention
Acetylsalicylic acid (ASA) at therapeutic concentrations
C
Comparator
Control (IL-18 stimulation without ASA)
O
Outcome
Cardiac fibroblast migration in a Matrigel invasion assaysurrogate

Acetylsalicylic acid inhibits IL-18-induced cardiac fibroblast migration by preventing RECK suppression and MMP9 activation, suggesting a potential protective mechanism against cardiac fibrosis.

Cite This Study

Siddesha et al. (2013) studied Cardiac fibrosis. Acetylsalicylic acid (ASA) was evaluated on IL-18-induced cardiac fibroblast migration. Acetylsalicylic acid inhibited IL-18-induced cardiac fibroblast migration by attenuating H2O2 generation, MMP9 activation, and RECK suppression.

synapsesocial.com/papers/6a89ab7e1e528df4f2ec69b6https://doi.org/10.1002/jcp.24511
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