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February 29, 2008AJP Heart and Circulatory Physiology

Resveratrol inhibits high glucose-induced PI3K/Akt/ERK-dependent interleukin-17 expression in primary mouse cardiac fibroblasts

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Why the study?

Does resveratrol inhibit high glucose-induced IL-17 expression and signaling in primary mouse cardiac fibroblasts?

Population

Primary mouse cardiac fibroblasts (mCFs)

Comparison

Resveratrol pretreatment vs High glucose without resveratrol, and low…

Design

Preclinical

Authors

KVKaliyamurthi VenkatachalamSMSrinivas MummidiDCDolores Cortez

Discussion

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Overview

Resveratrol may blunt hyperglycemia-driven fibroblast activation; leaves open whether it mitigates diabetic myocardial remodeling in vivo.

Structured PICO

Does resveratrol inhibit high glucose-induced IL-17 expression and signaling in primary mouse cardiac fibroblasts?

P
Population
Primary mouse cardiac fibroblasts (mCFs)
I
Intervention
Resveratrol pretreatment
C
Comparator
High glucose (25 mM D-glucose) without resveratrol, and low glucose (5 mM D-glucose + 20 mM mannitol) control
O
Outcome
IL-17 expression and secretionsurrogate

Resveratrol blocks high glucose-induced IL-17 expression and signaling in cardiac fibroblasts, highlighting its potential to ameliorate hyperglycemia-induced myocardial inflammation and remodeling.

Cite This Study

Venkatachalam et al. (2008) studied this question.

synapsesocial.com/papers/6a7561940b1b00a0ee09318fhttps://doi.org/10.1152/ajpheart.01363.2007
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