Population
Sheep Purkinje fibres and externally stimulated sheep ventricular trabeculae
Design
Preclinical
Authors
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Suggests dual inotropic mechanisms in sheep myocytes; leaves open pump-independent effects and clinical relevance in humans.
Cardiotonic steroids exhibit a dual inotropic mechanism in sheep cardiac tissue, including a low-dose positive inotropic effect independent of sodium pump inhibition.
Hart et al. (1983) studied this question.
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