Key result
The tissue-engineered textile-reinforced mitral valve (TexMi) demonstrated functional opening and closing cycles, extracellular matrix deposition, and a burst strength of 554.7 mmHg after 21 days.
Population
Ovine umbilical vein cells molded into a composite scaffold (fibrin gel and textile tubular structure)
Design
Preclinical
Follow-up
21 days
Authors
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Supports development of living mitral valve prostheses; hypothesis-generating for in vivo durability before clinical translation.
Absolute Event Rate: 554.7% vs 5272.3%
The TexMi tissue-engineered mitral valve demonstrates proof-of-principle for a living, textile-reinforced prosthesis capable of tissue development without contraction in vitro.
Moreira et al. (2014) studied Mitral valve disease (in vitro model) (n=3). TexMi (tissue-engineered textile-reinforced mitral valve) vs. Native ovine mitral valve was evaluated on Burst strength (mmHg). The tissue-engineered textile-reinforced mitral valve (TexMi) demonstrated functional opening and closing cycles, extracellular matrix deposition, and a burst strength of 554.7 mmHg after 21 days.
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