What question did this study set out to answer?

To evaluate high-risk clinical target volume coverage and organ-at-risk dose-volume histograms under Point A-based high-dose-rate brachytherapy for locally advanced cervical cancer.

January 1, 2018The Showa University Journal of Medical SciencesOpen Access

Dose-Volume Histogram Analysis in Point A-based Dose Prescription of High-dose-rate Brachytherapy for Cervical Carcinoma

View Full Paper

Ask AI

Bookmark

To evaluate high-risk clinical target volume coverage and organ-at-risk dose-volume histograms under Point A-based high-dose-rate brachytherapy for locally advanced cervical cancer.
Retrospective dosimetric evaluation of 68 patients with locally advanced cervical cancer treated with external beam radiation and high-dose-rate brachytherapy (6 Gy fractions; total 12–24 Gy to Point A) between December 2012 and March 2017.
Post-implant pelvic computed tomography scans were coregistered with diagnostic magnetic resonance imaging to re-contour high-risk clinical target volumes, bladder, and rectum according to ICRU Report 89 guidelines.
Mean HR-CTV D90 across all patients was 558.3 cGy (range: 228.7–1005.1 cGy), declining across clinical stages: Ib (646.4 cGy), 2a (579.3 cGy), 2b (545.2 cGy), 3a (556.6 cGy), 3b (451.3 cGy), and 4 (497.9 cGy).
HR-CTV D90 negatively correlated with target volume, and mean D2cm3 doses reached 678.1 cGy for the bladder and 511.9 cGy for the rectum, demonstrating inadequate tumor coverage in advanced disease stages.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Dosimetric study reveals insufficient target volume coverage with Point A brachytherapy in advanced cervical cancer, indicating the necessity of image-guided treatment planning.

Cite This Study

KOBAYASHI et al. (2018) studied this question.

synapsesocial.com/papers/6a89b0651fe1bad943eb36e1 https://doi.org/10.15369/sujms.30.227

View Full Paper

Ask AI

Bookmark

Implication

Dosimetric study reveals insufficient target volume coverage with Point A brachytherapy in advanced cervical cancer, indicating the necessity of image-guided treatment planning.

Dose-Volume Histogram Analysis in Point A-based Dose Prescription of High-dose-rate Brachytherapy for Cervical Carcinoma

Key Points

Discussion

Implication

Cite This Study

Dose-Volume Histogram Analysis in Point A-based Dose Prescription of High-dose-rate Brachytherapy for Cervical Carcinoma

Key Points

Discussion

Implication

Cite This Study