Key result
Vitreous levels of advanced glycation end products were positively correlated with vascular endothelial growth factor in patients with diabetic retinopathy sufficiently treated with photocoagulation (r = 0.44, p < 0.05).
Cross-Sectional (n=79)
Effect estimate: r = 0.44
Absolute Event Rate: 0.44% vs 0.26%
p-value: p=<0.05
Vitreous AGE levels positively correlate with VEGF in diabetic retinopathy patients sufficiently treated with photocoagulation, suggesting AGEs may induce VEGF expression via an ischemia-independent mechanism.
Should not change photocoagulation practice in diabetic retinopathy; hypothesis-generating for ischemia-independent AGE-VEGF pathways.
We investigated whether vitreous levels of advanced glycation end products (AGEs) were positively correlated with vascular endothelial growth factor (VEGF) in patients with diabetic retinopathy patients sufficiently treated with retinal photocoagulation. Vitreous AGE and VEGF levels were significantly higher in patients with diabetes than in controls. Positive correlation between AGE and VEGF was found in patients with diabetic retinopathy sufficiently treated with retinal photocoagulation (r = 0.44, p<0.05), but not in those who were insufficiently treated (r = 0.26, p = 0.18). The present observations suggest that AGE may induce VEGF expression in an ischaemia-independent mechanism. AGE could be one of the important determinants of VEGF in diabetic retinopathy without obvious ischaemic regions.
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Yokoi et al. (2007) conducted a cross-sectional in Diabetic retinopathy (n=79). Sufficient panretinal photocoagulation (S-PRP) vs. Insufficient photocoagulation (IS-RP) was evaluated on Correlation between vitreous levels of advanced glycation end products (AGEs) and vascular endothelial growth factor (VEGF) (r = 0.44, p=<0.05). Vitreous levels of advanced glycation end products were positively correlated with vascular endothelial growth factor in patients with diabetic retinopathy sufficiently treated with photocoagulation (r = 0.44, p < 0.05).
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