Key result
A 12-week lifestyle modification program of mild aerobic exercise and diet significantly lowered systolic blood pressure from 129.1 to 125.3 mmHg (p=0.0010), with the reduction mechanism influenced by nitric oxide bioavailability.
Why the study?
Does a 12-week lifestyle modification program of mild exercise and diet improve blood pressure and nitric oxide bioavailability in adults?
Cohort (n=132)
No
Does a 12-week lifestyle modification program of mild exercise and diet improve blood pressure and nitric oxide bioavailability in adults?
Absolute Event Rate: 125.3% vs 129.1%
p-value: p=0.0010
A 12-week lifestyle modification program of mild exercise and diet lowers blood pressure, with the mechanism of reduction influenced by individual changes in nitric oxide bioavailability and oxidative stress.
May support mild exercise and diet for BP lowering; leaves open causal nitric oxide role pending randomized confirmation.
Lifestyle modification is recommended as a non-pharmacological approach to treatment of hypertension. Many investigators have reported that exercise has antihypertensive effects, and various mechanisms have been proposed to explain this phenomenon. For example, nitric oxide (NO), which may be increased by exercise, has been reported to play a crucial role in preserving vessel homeostasis both by regulating vascular tone and by exerting anti-atherosclerotic effects. NO is known to be exquisitely sensitive to inactivation by superoxide radicals. However, the relationship between the blood pressure-lowering effect of lifestyle modification and NO bioavailability remains unknown. We investigated the effects of a 12-week lifestyle modification program consisting of mild exercise and diet on changes in blood pressure, plasma nitrate/nitrite (NOx), plasma nitrotyrosine, which is the footprint of NO interaction with reactive oxygen species, and plasma extracellular-superoxide dismutase (EC-SOD). The 12-week lifestyle modification program lowered blood pressure and increased plasma NOx. When the subjects were divided into two groups according to the change of plasma nitrotyrosine as an indicator of NO bioavailability, the subjects whose plasma nitrotyrosine decreased exhibited a significant relationship between the blood pressure-lowering effect of the lifestyle modification and the increase in EC-SOD, whereas those without a decrease in plasma nitrotyrosine exhibited a significant relationship between the blood pressure-lowering effect and the increase in maximum oxygen consumption. These results indicate that the level of NO bioavailability influences the mechanism of the blood pressure-lowering effect of aerobic exercise and diet.
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Ohta et al. (2005) conducted a cohort in Hypertension and normotension (n=132). Lifestyle modification program (mild aerobic exercise and diet counseling) vs. Baseline (before intervention) was evaluated on Systolic blood pressure (p=0.0010). A 12-week lifestyle modification program of mild aerobic exercise and diet significantly lowered systolic blood pressure from 129.1 to 125.3 mmHg (p=0.0010), with the reduction mechanism influenced by nitric oxide bioavailability.
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