Key result
Experimental models of cardio-renal, hepatic-renal syndromes, and hypoxic histochemical injury in rats are optimal for studying the pathogenesis and pharmacological correction of comorbid kidney pathology.
Why the study?
The study aimed to report modern experimental models of kidney diseases associated with comorbid pathological conditions to evaluate pathogenic mechanisms and pharmacological correction.
Experimental rat models induced by doxorubicin or exotoxins provide optimal platforms for studying the pathogenesis and pharmacological treatment of cardio-renal and hepatic-renal syndromes.
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These rat models support preclinical cardio-renal research; leaves open human translation pending validation.
The aim of our study is to report about modern models of kidney diseases associated with other pathological conditions for experimental studies of pathogenic mechanisms and efficacy of pharmacological correction.The study deals with experimental models reasonably to be applied in investigation of comorbid pathology pathogenesis and efficacy of its pharmacological correction. The attention is focused on the models of cardio-renal, hepatic-renal syndromes and multiple organ hypoxic histochemical injury simulated in laboratory rats. These models are characterized by easy modeling, simulation of comorbidity pathogenesis, acute and chronic periods of diseases available, induced by the antibiotic Doxorubicin or exotoxins – corrosive sublimate, sodium nitrite, and 2,4-dinitrophenol.Conclusions. The models of cardio-renal, hepatic-renal syndromes and hypoxic histochemical injury of the body are found to be optimal to perform multipurpose studies of physiological, pathophysiological, pharmacological directions with maximal similarity of the results obtained to clinical-therapeutic peculiarities of comorbid pathology.
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Серединська et al. (2019) conducted a review in Comorbid kidney diseases (cardio-renal, hepatic-renal syndromes, hypoxic injury). Experimental animal models was evaluated. Experimental models of cardio-renal, hepatic-renal syndromes, and hypoxic histochemical injury in rats are optimal for studying the pathogenesis and pharmacological correction of comorbid kidney pathology.
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