Key result
Interstitial cells co-expressing cellular prion protein and cardiac troponin T were identified as native atypically-shaped cardiomyocytes that survive life-long in mouse and human ventricles and spontaneously develop into beating cells in culture.
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Does not alter clinical practice; leaves open their role in cardiac repair and regenerative potential.
Omatsu‐Kanbe et al. (2014) studied Normal cardiac tissue. Cellular prion protein (PrP) and cardiac troponin T (cTnT) expression vs. Cells not expressing PrP/cTnT was evaluated on Presence and development of PrP and cTnT-marked interstitial cells into beating cardiomyocytes. Interstitial cells co-expressing cellular prion protein and cardiac troponin T were identified as native atypically-shaped cardiomyocytes that survive life-long in mouse and human ventricles and spontaneously develop into beating cells in culture.
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