October 1, 1994
Plasma renin activity and insulin sensitivity in normotensive subjects.
Why the study?
Is there a relationship between plasma renin activity and insulin sensitivity in normotensive subjects?
Population
25 normotensive subjects
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Supports inverse renin-insulin sensitivity association in normotensives; hypothesis-generating and requires prospective studies before clinical relevance.
Structured PICO
Is there a relationship between plasma renin activity and insulin sensitivity in normotensive subjects?
P
Population
25 normotensive subjects
O
Outcome
Correlation between supine plasma renin activity and insulin-mediated glucose uptake (measured via euglycemic clamp technique)surrogate
In normotensive subjects, higher plasma renin activity is associated with lower insulin sensitivity, which may reflect a metabolic compensation mechanism.
Cite This Study
Townsend et al. (1994) studied this question.