Key result
A decreased change in low-frequency heart rate variability (ΔLF%) before and after hemodialysis was independently associated with increased overall mortality (HR 0.978 per 1 nu increase).
Why the study?
Does the change in heart rate variability before and after hemodialysis predict overall and cardiovascular mortality in hemodialysis patients?
Cohort (n=182)
No
Does the change in heart rate variability before and after hemodialysis predict overall and cardiovascular mortality in hemodialysis patients?
Hazard Ratio: 0.978 (95% CI 0.961–0.996)
p-value: p=0.019
The change in heart rate variability (ΔLF%) before and after hemodialysis is an independent predictor of overall and cardiovascular mortality, offering incremental prognostic value over clinical factors and pre-dialysis HRV alone.
ΔLF% may aid mortality risk stratification in hemodialysis; leaves open prospective validation and clinical utility.
Low heart rate variability (HRV) has been recognized to correlate with adverse cardiovascular (CV) outcomes in hemodialysis (HD) patients. It has been reported that HRV might be improved after HD, but whether the improved HRV after HD predicts a better CV prognosis remains to be determined. This study examined the ability of the change in HRV before and after HD in predicting overall and CV mortality in HD patients. This study enrolled 182 patients under maintenance HD. HRV was examined to assess changes before and after HD. The change in HRV (ΔHRV) was defined as post-HD HRV minus pre-HD HRV. During a median follow-up period of 35.2 months, 29 deaths (15.9%) were recorded. Multivariate analysis showed that decreased ΔLF% was associated with increased overall (hazard ratios [HR], 0.978; 95% confidence interval [CI], 0.961-0.996; p = 0.019) and CV mortality (HR, 0.941; 95% CI, 0.914-0.970; p < 0.001), respectively. Moreover, adding ΔLF% to a clinical model provided an additional benefit in the prediction of overall (p = 0.002) and CV mortality (p < 0.001). HRV change before and after HD (ΔHRV) is an useful clinical marker, and it is stronger than HRV before HD in predicting overall and CV mortality.
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Chen et al. (2016) conducted a cohort in End-stage renal disease on maintenance hemodialysis (n=182). Change in low-frequency heart rate variability (ΔLF%) was evaluated on Overall mortality (HR 0.978, 95% CI 0.961-0.996, p=0.019). A decreased change in low-frequency heart rate variability (ΔLF%) before and after hemodialysis was independently associated with increased overall mortality (HR 0.978 per 1 nu increase).
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