Atrial natriuretic factor may regulate fetoplacental blood flow by inhibiting the vasoconstrictor action of angiotensin II.
Hypothesis-generating for fetoplacental vascular regulation in animal models; leaves open translation to human pregnancy.
We have identified two classes of membrane receptor for atrial natriuretic peptide (KD (dissociation constant) 0.2, 70.1 nmol/L) and angiotensin II (KD 1.7 nmol/L, 15.2 nmol/L) in human fetoplacental vasculature. In addition, in the isolated perfused placenta atrial natriuretic peptide inhibited the vasoconstrictor action of angiotensin II. These findings suggest that atrial natriuretic factor may regulate fetoplacental blood flow.
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McQueen et al. (1990) studied this question.
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