Evidence for a functional renin-angiotensin system in full-term fetoplacental unit

View Full Paper

Ask AI

Bookmark

Population

Full-term human placentas from uncomplicated pregnancies (n=7 for umbilical venous blood measurements)

Comparison

Angiotensin II perfusion and receptor binding… vs Saralasin for perfusion studies

Design

Preclinical

Authors

Discussion

Does not yet support targeting fetal RAS clinically; leaves open its role in human placental disorders pending confirmatory studies.

Population

Full-term human placentas from uncomplicated pregnancies (n=7 for umbilical venous blood measurements)

Intervention

Angiotensin II perfusion and receptor binding assays

Comparator

Saralasin (competitive angiotensin II receptor antagonist) for perfusion studies

Outcome

Perfusion pressure and angiotensin II receptor binding propertiessurrogate

This study provides evidence for an active, functional renin-angiotensin system in the human fetal circulation that may modulate placental perfusion.

Wílkes et al. (1985) studied this question.

View Full Paper

Ask AI

Bookmark