Key result
Preoperative plasma aldosterone level was the strongest predictor of complete remission of type 2 diabetes 12 months after bariatric surgery.
Why the study?
Does preoperative plasma aldosterone predict complete remission of type 2 diabetes in patients with obesity undergoing bariatric surgery?
Cohort (n=79)
Does preoperative plasma aldosterone predict complete remission of type 2 diabetes in patients with obesity undergoing bariatric surgery?
Preoperative plasma aldosterone levels may serve as a strong predictor for complete remission of type 2 diabetes following bariatric surgery.
Weight loss and insulin resistance reduction suffice for short-term T2D remission after bariatric surgery; leaves open whether incomplete hormonal restoration predicts later relapse.
INTRODUCTION: Bariatric surgery (BS) has beneficial effects on body weight and type 2 diabetes. However, 44-52%, 20-40%, and 19-25% of patients with type 2 diabetes who undergo sleeve gastrectomy, sleeve gastrectomy with duodenal-jejunal bypass, and Roux-en-Y gastric bypass, respectively, show insufficient improvement 1 year after BS. It is thus important to predict the improvement in type 2 diabetes before BS. Many hormones are related to hyperglycemia. However, the relationship between hormones and improvement in type 2 diabetes after BS has not been studied. We aimed to evaluate the relationship between the improvement in type 2 diabetes and hormones in patients with obesity and type 2 diabetes who underwent BS. METHODS: We retrospectively reviewed 79 patients with obesity and type 2 diabetes who underwent BS, with a follow-up period of 12 months. We analyzed the relationship between some clinical parameters and complete remission (CR) of type 2 diabetes after BS. Patients were divided into two groups (type 2 diabetes CR and non-CR). Multiple regression analysis was performed to determine the parameters associated with type 2 diabetes resolution after BS. RESULTS: BS significantly improved body weight and glucose metabolism. Preoperative liver function, glycated hemoglobin (HbA1c), insulin secretion (homeostatic model assessment [HOMA]2-%B), renin activity, plasma aldosterone level, and duration of type 2 diabetes were significantly different between the CR and non-CR groups. Multiple regression analysis showed that preoperative HbA1c, HOMA2-%B, aldosterone concentration, and duration of type 2 diabetes were predictors of CR of type 2 diabetes after BS. Plasma aldosterone was the strongest predictor. DISCUSSION/CONCLUSION: Preoperative plasma aldosterone levels were related to the CR of type 2 diabetes after BS. Measuring plasma aldosterone levels preoperatively is useful for predicting the CR of type 2 diabetes after BS.
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Ohira et al. (2022) conducted a cohort in Obesity and type 2 diabetes (n=79). Preoperative plasma aldosterone level was evaluated on Complete remission of type 2 diabetes. Preoperative plasma aldosterone level was the strongest predictor of complete remission of type 2 diabetes 12 months after bariatric surgery.
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