Key result
Levobupivacaine (20 microM) induced a greater block of HERG channels (67.5%) compared to bupivacaine (52.7%) and ropivacaine (55.5%) (P<0.05), demonstrating stereoselective block.
Population
HERG channels stably expressed in CHO cells
Comparison
Levobupivacaine, ropivacaine, and bupivacaine vs Comparison between the different local…
Design
Preclinical
Authors
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Hypothesis-generating for stereoselective cardiotoxicity among local anesthetics; clinical relevance of HERG block differences requires human confirmation.
Absolute Event Rate: 67.5% vs 52.7%
p-value: p=<0.05
Levobupivacaine, ropivacaine, and bupivacaine block HERG channels in a concentration-, time-, and state-dependent manner, with levobupivacaine demonstrating a more potent, stereoselective block compared to dextrobupivacaine.
González et al. (2002) studied this question. Levobupivacaine, ropivacaine, and bupivacaine vs. Each other was evaluated on Block of HERG channels at the end of 5 s pulses to -10 mV (p=<0.05). Levobupivacaine (20 microM) induced a greater block of HERG channels (67.5%) compared to bupivacaine (52.7%) and ropivacaine (55.5%) (P<0.05), demonstrating stereoselective block.
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