Key result
Buprenorphine induction in a patient with methadone-related torsade de pointes resulted in no clinically important QTc prolongation, suggesting it may be a safe alternative to oral methadone.
Why the study?
Does buprenorphine prevent QTc prolongation in patients with methadone-related torsade de pointes?
Population
1 patient with opioid addiction who developed torsade de pointes while receiving high-dose methadone
Comparison
Buprenorphine vs High-dose methadone (prior therapy)
Design
Case_report
Authors
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Hypothesis-generating for buprenorphine in methadone-related torsade de pointes; prospective trials needed before any practice consideration.
Case Report (n=1)
Does buprenorphine prevent QTc prolongation in patients with methadone-related torsade de pointes?
Buprenorphine may be a safe alternative to oral methadone in patients with opioid addiction who develop methadone-related torsade de pointes.
Krantz et al. (2005) conducted a case report in Methadone-related Torsade de Pointes (n=1). Buprenorphine vs. Methadone was evaluated on QTc prolongation. Buprenorphine induction in a patient with methadone-related torsade de pointes resulted in no clinically important QTc prolongation, suggesting it may be a safe alternative to oral methadone.
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