May 11, 2010Biochemistry

Hypertrophic Cardiomyopathy-Linked Mutation D145E Drastically Alters Calcium Binding by the C-Domain of Cardiac Troponin C

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Population

In vitro model of cardiac troponin C with hypertrophic cardiomyopathy-linked mutations A8V, E134D, and D145E

Comparison

Hypertrophic cardiomyopathy-linked mutations… vs Wild-type cardiac troponin C

Design

Preclinical

Authors

NSNicholas SwindleUniversity of Houston STSvetlana B. TikunovaThe Ohio State University

Discussion

Member takes

Implication

Does not yet alter HCM management; extends biochemical data on troponin C but requires in vivo validation.

Structured PICO

Population

In vitro model of cardiac troponin C with hypertrophic cardiomyopathy-linked mutations A8V, E134D, and D145E

Intervention

Hypertrophic cardiomyopathy-linked mutations A8V, E134D, and D145E

Comparator

Wild-type cardiac troponin C

Outcome

Calcium and magnesium binding properties of the C-domain sitessurrogate

The HCM-linked D145E mutation drastically alters calcium binding by the C-domain of cardiac troponin C, highlighting its importance in proper regulatory function.

Cite This Study

Swindle et al. (2010) studied this question.

synapsesocial.com/papers/6a89b8bf1acf8e321fbd6682 https://doi.org/10.1021/bi100400h

Topics

Hypertrophic cardiomyopathy

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Hypertrophic Cardiomyopathy-Linked Mutation D145E Drastically Alters Calcium Binding by the C-Domain of Cardiac Troponin C

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Hypertrophic Cardiomyopathy-Linked Mutation D145E Drastically Alters Calcium Binding by the C-Domain of Cardiac Troponin C

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider