Why the study?
Does clopidogrel reduce the combined risk of ischaemic stroke, myocardial infarction, or vascular death in patients with atherosclerotic vascular disease compared to aspirin?
Population
19,185 patients with atherosclerotic vascular disease manifested as recent ischaemic stroke, recent…
Comparison
Clopidogrel 75 mg single daily oral dose vs Aspirin 325 mg
Design
Review, randomized, double-blind
Follow-up
1-3 years
Authors
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Clopidogrel may suit aspirin-intolerant patients; leaves open relevance versus modern regimens in updated meta-analyses.
Does clopidogrel reduce the combined risk of ischaemic stroke, myocardial infarction, or vascular death in patients with atherosclerotic vascular disease compared to aspirin?
Clopidogrel is an effective and well-tolerated alternative to aspirin for the secondary prevention of ischaemic events in patients with atherosclerotic vascular disease, offering a modest benefit with fewer gastrointestinal side effects.
D’Sa et al. (1999) studied this question.
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