Erythropoietin and Erythropoiesis

Editorials1 August 1966Erythropoietin and ErythropoiesisCLIFFORD W. GURNEY, M.D.CLIFFORD W. GURNEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-2-377 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInvestigations of the mechanism of regulation of red cell production have received their impetus in recent years from the classical experiments of Reissman (1), which clearly established the existence of a humoral erythropoietic factor, and the studies of Jacobson, Plzak, Fried, and Goldwasser (2) and Jacobson, Gurney, and Goldwasser (3), which made available a series of simple, sensitive procedures for its bioassay. In the last 10 years, there has been rapid progress in understanding of the biochemical nature, mechanism of action, and role in both physiological erythropoiesis and abnormal states of red cell formation of erythropoietin, the hormonal regulator of...References1. REISSMANN KR: Studies on the mechanism of erythropoietic stimulation in parabiotic rats during hypoxia. Blood 5: 372, 1950. CrossrefMedlineGoogle Scholar2. JACOBSONPLZAKFRIEDGOLDWASSER LOLWE: Plasma factor(s) influencing red cell production. Nature (London) 177: 1240, 1956. CrossrefMedlineGoogle Scholar3. JACOBSONGURNEYGOLDWASSER LOCWE: The control of erythropoiesis. Advances Intern. Med. 10: 297, 1960. MedlineGoogle Scholar4. GOLDWASSER E: Biochemical control of erythroid cell development, in Current Topics in Developmental Biology, edited by MOSCONA, A. A., MONROY, A. Academic Press, Inc., New York. In press. Google Scholar5. 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Treatment of myeloid metaplasia. New Eng. J. Med. 264: 103, 1961. CrossrefMedlineGoogle Scholar23. SHAHIDIDIAMOND NTLK: Testosterone-induced remission in aplastic anemia of both acquired and congenital types. Further observations in 24 cases. Ibid., p. 953, 1961. Google Scholar24. FRIEDDEGOWINGURNEY WRCW: Erythropoietic effect of testosterone in the polycythemic mouse. Proc. Soc. Exp. Biol. Med. 117: 839, 1964. CrossrefMedlineGoogle Scholar25. NAETSWITTEK JPM:Étude du mécanisme d'action des androgènes sur l'érythropoièse. C. R. 259: 3371, 1964. Google Scholar26. MIRANDGORDONWENIG EAASJ: Mechanism of testosterone action in erythropoiesis. Nature (London) 206: 270, 1965. CrossrefMedlineGoogle Scholar27. JANDAFRIEDGURNEY WEWCW: Combined effect of cobalt and testosterone on erythropoiesis. Proc. Soc. Exp. Biol. Med. 120: 443, 1965. CrossrefMedlineGoogle Scholar28. DEGOWINGURNEY RLCW: Hemopoiesis in polycythemia vera after phlebotomy and iron therapy. Arch. Intern. Med. (Chicago) 114: 424, 1964. CrossrefMedlineGoogle Scholar29. GURNEY CW: Polycythemia vera and some possible pathogenetic mechanisms. Ann. Rev. Med. 16: 169, 1965. CrossrefMedlineGoogle Scholar30. ADAMSONFINCH JWCA: Mechanisms of erythroid marrow activation. Trans. Ass, Amer. Physicians. In press, 1966. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Argonne Cancer Research Hospital * Departments of Medicine and Physiology The University of Chicago Chicago, Ill.*Operated by the University of Chicago for the United States Atomic Energy Commission. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byErythropoietinUntersuchungen der Erythropoetinaktivität und zur Frage eines Erythropoetininhibitors in Plasmakonzentraten von Patienten mit Polycythaemia veraCurrent Status of ErythropoietinPhysiologic and Pathophysiologic Effects of AnemiaAN ANALYSIS OF HYPOPLASTIC ANAEMIA WITH SPECIAL REFERENCE TO THE USE OF OXYMETHOLONE (”ADROYD“) IN ITS THERAPYErythropoietin 1 August 1966Volume 65, Issue 2Page: 377-381KeywordsBioassays and physiological analysisErythropoiesisErythropoietin Issue Published: 1 August 1966 PDF downloadLoading ...