August 1, 1990AJP Heart and Circulatory Physiology

Age-related changes in myocardial relaxation and sarcoplasmic reticulum function

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Population

Isolated, perfused adult (n=8) and newborn (n=6) guinea pig hearts

Comparison

Maximum isoproterenol stimulation vs Comparison between adult and newborn hearts

Design

Preclinical

Authors

TKTina M. KaufmanOregon Health & Science University JHJureta W. HortonThe University of Texas Southwestern Medical Center DWD. Jean WhiteUniversity of Cambridge

Discussion

Member takes

Implication

Developmental lusitropic differences confirmed in animals; leaves open translation to human pediatric cardiology.

Structured PICO

Population

Isolated, perfused adult (n=8) and newborn (n=6) guinea pig hearts

Intervention

Maximum isoproterenol stimulation

Comparator

Comparison between adult and newborn hearts

Outcome

Change in time constant of isovolumic relaxation (tau) and Ca2+ transport by the sarcoplasmic reticulumsurrogate

Developmental differences in sarcoplasmic reticulum calcium sequestration capacity contribute to age-related variations in myocardial relaxation response to beta-adrenergic stimulation.

Cite This Study

Kaufman et al. (1990) studied this question.

synapsesocial.com/papers/6a89bb5a9be9d02581bd7b29 https://doi.org/10.1152/ajpheart.1990.259.2.h309

View Full Paper

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Age-related changes in myocardial relaxation and sarcoplasmic reticulum function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Age-related changes in myocardial relaxation and sarcoplasmic reticulum function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider