Population
Intact anesthetized dogs with markers chronically attached to the mitral annulus and the valve cusps
Comparison
Varied ventricular outflow resistance vs Control state (normal aortic pressure)
Design
Preclinical
Authors
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Should not change clinical atrial assessment; leaves open translation of afterload effects on emptying from canine models to humans.
In an intact dog model, increased aortic pressure leads to increased maximal left atrial area and decreased percent emptying, suggesting atrial emptying may be near maximal at rest.
Tsakiris et al. (1977) studied this question.
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