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January 1, 1973Pure and Applied ChemistryOpen Access

The synthesis of fluorinated carbohydrates

A. B. Foster J.H. Westwood

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Key Points

To review chemical methodologies and synthetic strategies for the preparation of fluorinated carbohydrate derivatives.
Literature synthesis examining fluorination reagents and stereoselective installation of fluorine atoms onto saccharide scaffolds.
Evaluation of nucleophilic and electrophilic fluorination protocols tailored for complex carbohydrate intermediates.
Fluorination alters the electronic, conformational, and metabolic stability of carbohydrate molecules without introducing severe steric bulk.
Various selective fluorination methods enable precise site-specific modification across diverse monosaccharide and oligosaccharide building blocks.

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Implication

Chemical review outlines synthetic routes to fluorinated carbohydrates, highlighting strategies for drug discovery.

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Cite This Study

Foster et al. (1973) studied this question.

synapsesocial.com/papers/6a89c1ab9be9d02581bd7d3a https://doi.org/10.1351/pac197335020147

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