Pooled Human Plasma as a Volume Expander

POOLED human plasma, stored for six months or longer at 30 to 32°C. to prevent the transmission of viral hepatitis,1 , 2 satisfies most criteria for a suitable plasma-volume expander in emergency situations. Until recently, its administration has been considered to be free from side reactions; Miller and Tisdall3 analyzed 10,000 pooled plasma transfusions and found allergic reactions in only 1 per cent. However, this reliability of plasma as a volume expander has now been questioned. Freedman and his associates4 and Hutchison et al.5 , 6 have demonstrated that the administration of fresh, nonautologous plasma usually results in a rapid loss of volumes greater . . .