Prostaglandin F2 alpha infusion can induce severe vasospastic angina and multiple segmental coronary artery spasms.
PGF2α infusion may provoke multivessel spasm; leaves open its role in clinical vasospastic angina.
A 56 year old woman underwent cholecystectomy. Postoperative paralytic ileus was treated with an intravenous infusion of prostaglandin F2 alpha. During infusion she complained of oppressive chest pain. This was accompanied by ST segment depression, and was relieved by sublingual glyceryl trinitrate. Coronary arteriography did not show significant stenosis, but subsequent intravenous infusion of prostaglandin F2 alpha provoked multiple segmental spasm of both the right and left coronary arteries.
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Shigematsu et al. (1993) studied this question.
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