Why the study?
Does tetrodotoxin reduce the in vitro invasiveness of prostatic cancer cell lines expressing voltage-activated Na+ currents?
Population
Two rodent prostatic cancer cell lines (highly metastatic Mat-Ly-Lu cells and weakly metastatic AT-2 cells)
Comparison
Tetrodotoxin (600 nM) vs Untreated/control conditions
Design
Preclinical
Authors
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May reduce invasiveness in Na+-expressing prostate cancer cells in vitro; leaves open in vivo relevance and clinical translation.
Does tetrodotoxin reduce the in vitro invasiveness of prostatic cancer cell lines expressing voltage-activated Na+ currents?
Voltage-activated Na+ currents are expressed in highly metastatic prostatic cancer cells and contribute to their in vitro invasiveness.
Grimes et al. (1995) studied this question.
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