On the Excretion of Bile Acid Derivatives in Feces of‘ Rats fed Cholic Acid‐24‐14C and Chenodesoxycholic Acid‐24‐14C.: Bile Acids nnd Steroids 19.

Summary. Cholic acid‐24‐14C and chenodesoxycholic acid‐24‐14C were given intraperitoneally to rats and the excretory products in the feces were studied: 1. The given amount is practically completely recovered in feces within 10 days. 2. The acidic products in the feces have been separated by partition chromatography. Only minor amounts were found in the conjugated form. The complicated patterns indicate extensive changes on the bile acid molecule by microbial enzyme systems. 3. The different bands observed on the chromatograms of fecal material after administering labelled cholic and chenodesoxy‐cholic acid together show the same bands that are observed after administration of ring labelled cholesterol.