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October 1, 2011Methodist DeBakey Cardiovascular JournalOpen Access

Balancing Hemostasis And Thrombosis In Interventional Vascular Medicine And Surgery

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Population

Patients presenting with acute coronary syndromes requiring antithrombotic therapy and revascularization.

Design

Review

Authors

JBJohn M. BuerglerHouston MethodistNeal S. KleimanNeal S. KleimanInterventional / Structural Cardiology

Discussion

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Implication

Supports bleeding risk assessment in ACS; leaves open whether CRUSADE-guided therapy improves outcomes in randomized trials.

Structured PICO

P
Population
Patients presenting with acute coronary syndromes (ACS) requiring antithrombotic therapy and revascularization.
I
Intervention
Individualized antithrombotic treatments (including aspirin, clopidogrel, prasugrel, heparin, bivalirudin, and glycoprotein IIb/IIIa inhibitors).

Careful assessment of bleeding risk factors using standardized scores allows for the customization of antithrombotic therapy in ACS patients to minimize mortality from both ischemic and hemorrhagic events.

Cite This Study

Buergler et al. (2011) studied this question.

synapsesocial.com/papers/6a89cd450e1a8f7244fd5d77https://doi.org/10.14797/mdcj-7-4-19

Topics

Dual antiplatelet therapyAnticoagulation in AF
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Excess Dosing of Antiplatelet and Antithrombin Agents in the Treatment of Non–ST-Segment Elevation Acute Coronary Syndromes2005 · 677 citations
  2. 2The TIMI Risk Score for Unstable Angina/Non–ST Elevation MI2000 · 3,280 citations
  3. 3Impact of Major Bleeding on 30-Day Mortality and Clinical Outcomes in Patients With Acute Coronary Syndromes2007 · 803 citations
  4. 4Baseline Risk of Major Bleeding in Non–ST-Segment–Elevation Myocardial Infarction2009 · 1,024 citations
  5. 5Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes2007 · 6,825 citations