September 14, 2012HaematologicaOpen Access

Pulmonary hypertension in POEMS syndrome

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Structured PICO

Population

154 patients with POEMS syndrome (median age 46-47, 55-64% male) evaluated by duplex echocardiography at diagnosis, divided into those with pulmonary hypertension (estimated sPAP ≥50 mmHg, n=42) and without pulmonary hypertension (n=112).

Outcome

Overall survivalhard clinical

Pulmonary hypertension is a common complication in POEMS syndrome associated with extravascular volume overload and significantly worse overall survival, though it is often reversible with active treatment of the underlying disease.

Limitations

Retrospective nature
Lack of hemodynamic data from right heart catheterization
Estimated sPAP from DE is subject to variations
Big differences in the time to follow-up DE

Discussion

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Implication

PH screening merits consideration in POEMS syndrome; extends prognostic associations but needs prospective validation.

Cite This Study

J et al. (2012) studied this question.

synapsesocial.com/papers/6a89cef0b1e5d05ea8ec886b https://doi.org/10.3324/haematol.2012.073031

View Full Paper

Ask AI

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Pulmonary hypertension in POEMS syndrome

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Pulmonary hypertension in POEMS syndrome

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider