Spectroscopic analysis reveals the molecular structure of factor IV in Pseudomonas denitrificans, indicating macrocyclic ring contraction yields a C-1 acetyl group during vitamin B12 synthesis.
13 C Labelling and NMR experiments establish the structure of factor IV, the oxidized form of the tetramethylated intermediate on the biosynthetic pathway to precorrin-6x 2 in Pseudomonas denitrificans, thus demonstrating that the contraction of the macrocycle leads to an acetyl derivative at C-1.
No takes yet. Share an insight, caveat, or question.
Thibaut et al. (1993) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: