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July 1, 1940Annals of Internal Medicine

Concerning the Correlation of the Pathology and Symptoms of Coronary Artery Disease

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FSFRED M. SMITHUniversity of Iowa

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Implication

Reinforces caution in linking CAD pathology to symptoms clinically; leaves open refined correlation research.

Key Points

  • To examine the relationship between structural pathological findings in coronary artery disease and their diverse clinical manifestations.
  • Narrative synthesis of clinical, autopsy, and experimental literature on coronary occlusive disease.
  • Evaluation of cardiac enlargement, vascular occlusion, and collateral vessel development across historical cohorts, including an autopsy series of 113 advanced cases.
  • Extensive coronary arteriosclerosis frequently occurs without accompanying heart enlargement, preserving normal cardiac size even in advanced disease.
  • Clinical symptoms such as chest pain or infarction correlate inconsistently with vascular lesions due to compensatory collateral circulation and variable neurovascular responses.

Cite This Study

FRED M. SMITH (1940) studied this question.

synapsesocial.com/papers/6a89d49c755d28965dfd58a6https://doi.org/10.7326/0003-4819-14-1-65
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CORONARY THROMBOSIS WITHOUT PAIN: ITS INCIDENCE AND PATHOLOGY1932 · 24 citations
  2. 2ANATOMIC FINDINGS IN ESSENTIAL HYPERTENSION1925 · 83 citations
  3. 3The nature of the vascular communications between the coronary arteries and the chambers of the heart1933 · 323 citations
  4. 4VARIATIONS IN THE ANASTOMOSIS OF THE CORONARY ARTERIES AND THEIR SEQUENCES1924 · 21 citations