What question did this study set out to answer?

Determine whether tumor metabolic parameters measured on prone dedicated breast PET/MRI between 30 and 55 minutes post-injection agree within a 10% clinical margin with whole-body PET/MRI performed at 60 minutes.

December 3, 2025Nuclear Medicine Communications

Metabolic parameters on [18F]fluoro-2-deoxy-d-glucose PET/MRI: feasibility study comparing standardized uptake value quantification obtained from dedicated breast and whole-body scans within a single protocol in breast cancer patients

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Authors

IEIris van ElferenMaastricht University SVSofia C. VazChampalimaud Foundation PNPatty J. NelemansMaastricht University

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Implication

Feasibility study demonstrates tumor uptake values on dedicated breast PET/MRI match whole-body scans within a 10% margin in breast cancer patients, supporting single-session dual imaging.

Key Points

Determine whether tumor metabolic parameters measured on prone dedicated breast PET/MRI between 30 and 55 minutes post-injection agree within a 10% clinical margin with whole-body PET/MRI performed at 60 minutes.
Evaluated 20 breast cancer patients receiving a combined [18F]FDG-PET/MRI protocol incorporating both dedicated breast scans (bpPET/MRI) and whole-body scans (wbPET/MRI).
Calculated maximum and mean standardized uptake values (SUVmax and SUVmean) for index tumors, contralateral breast tissue, liver, and blood pool every 5 minutes from 30 to 55 minutes on bpPET/MRI and compared them to reference wbPET/MRI values at 60 minutes.
The majority of PET/MRI scans showed SUV variations that stayed within the acceptable 10% margin across all timepoints.
At 45 and 50 minutes post-injection, the mean percentage difference for tumor SUVmax and SUVmean relative to 60-minute scans was less than 1.3% to 3.6%.
Contralateral breast and liver SUVs generally remained within the 10% threshold, whereas blood pool SUV measurements showed divergence.

Cite This Study

Elferen et al. (2025) studied this question.

synapsesocial.com/papers/6a89d4d0ab4588dbccfb9be3 https://doi.org/10.1097/mnm.0000000000002091

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Implication

Feasibility study demonstrates tumor uptake values on dedicated breast PET/MRI match whole-body scans within a 10% margin in breast cancer patients, supporting single-session dual imaging.

Metabolic parameters on [18F]fluoro-2-deoxy-d-glucose PET/MRI: feasibility study comparing standardized uptake value quantification obtained from dedicated breast and whole-body scans within a single protocol in breast cancer patients

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Cite This Study

Metabolic parameters on [18F]fluoro-2-deoxy-d-glucose PET/MRI: feasibility study comparing standardized uptake value quantification obtained from dedicated breast and whole-body scans within a single protocol in breast cancer patients

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