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Identified virus-like particles in the synovial fluid of rheumatoid arthritis patients, suggesting a potential viral involvement in its pathogenesis.
Based on the elevated expression of oncogenes in proliferating transformed-appearing synoviocytes we searched for the possible involvement of a viral agent in the pathogenesis of RA. We report the detection of virus-like particles with retroviral C type morphology in SF, which lack the typical morphologic as well as immunohistochemical features of the human T-lymphotropic and immunodeficiency viruses.
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Stransky et al. (1993) studied this question.
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